Atherosclerosis: Risks, Mechanisms, and Therapies

Marc Notes: Includes bibliographical references and index. Table of Contents: Contributors ix Foreword"Joseph Loscalzo "xv Preface"Eric N. Olson "xvii Section I: Risk Factors: Old and New 1 1 Lipoproteins 3"Ming-Lin Liu and Daniel J. Rader" 2 Role of Dysglycemia in Atherosclerosis 15"David R. Clemmons" 3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27"Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt" 4 Inflammation 43"Caitlin Collins, Ellie Tzima, and Cam Patterson" 5 Homocysteine: A Controversial Cardiovascular Risk Factor 53"Sanjana Dayal and Steven R. Lentz" 6 Hypertension as a Risk Factor for Atherosclerosis 63"Annet Kirabo and David G. Harrison" 7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77"Paul Johnson, Jack Kuritzky, and Marschall Runge" 8 Life Style 93"Wayne E. Cascio" Section II: Cellular Mechanisms 105 9 Endothelial Cells 107"G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain" 10 Vascular Smooth Muscle Cells 117"Dario F. Riascos-Bernal and Nicholas E. S. Sibinga" 11 Fibroblasts 129"Christopher Mack" 12 Monocytes and Macrophages in Atherosclerosis 141"Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang" 13 Lymphocytes and Atherosclerosis 155"Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang" 14 Stem Cells 173"Arjun Deb" 15 Platelets 187"Jerry Ware and Adam Corken" 16 Development and Use of Mouse Models of Atherosclerosis 197"Peggy Robinet and Jonathan D. Smith" Section III: Molecular Mechanisms 207 17 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209"Hong Lu and Alan Daugherty" 18 The Role of Caveolae and Caveolins in Atherogenesis 221"Victor Rizzo" 19 Lysosomal Molecular Derangements in Atherosclerosis 235"Pin-Lan Li and Yang Zhang" 20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247"Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen" 21 Paraoxonases 257"Srinivasa T. Reddy" 22 Prostanoids, Their Receptors, and Atherogenesis 267"Domenico PraticO" 23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279"Uwe J. F. Tietge" 24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291"Kevin Jon Williams and Edward A. Fisher" 25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313"Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck" 26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329"Michael V. Autieri" 27 E CM and Atherosclerosis 343"Jie Du, Ying Wang, and Lixin Jia" Section IV: Biochemical Mechanisms 353 28 Effects of Nitric Oxide on Atherosclerosis 355"Terrence Pong and Paul L. Huang" 29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365"William Durante" 30 Roles of Reactive Oxygen Species in Physiology and Pathology 379"Ping Song and Ming-Hui Zou" 31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393"Elvis A. Peter, Jai Varma, and Christopher G. Kevil" 32 Methylation and Atherosclerosis 405"Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang" 33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423"Shusheng Wang and Chastain Anderson" 34 Posttranslational Modifications: Role in Atherosclerosis 437"Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk" 35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453"Katherine J. Elliott and Satoru Eguchi" 36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467"Thomas P. Vacek, Diana Neamtu, and Suresh C. Tyagi" Section V: Clinical Management 479 37 Impact of Preventive Therapies on Clinical Management and Outcomes 481"Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling" 38 Risk Stratification in Clinical Practice 495"Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr." 39 Molecular Imaging 503"Arun K. Thukkani and Farouc A. Jaffer" 40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517"Andrew J. Sampson, Timir Paul, and George A. Stouffer" 41 Targeted Molecular Therapeutics for Atherosclerosis 533"Lantz C. Mackey and Jonathon W. Homeister" 42 High-Density Lipoprotein Therapies--Then and Now 545"Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr." 43 Stem Cell Therapeutics 557"Mei Mei Wong and Qingbo Xu" 44 Advances in Surgical Revascularization 567"Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr." Index 579