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D-dopachrome Tautomerase (D-dt): Functional Homologue or Cross-regulator of Macrophage Migration Inhibitory Factor (Mif)?
Wibke Karin Schulte
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D-dopachrome Tautomerase (D-dt): Functional Homologue or Cross-regulator of Macrophage Migration Inhibitory Factor (Mif)?
Wibke Karin Schulte
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a pivotal regulator of the immune response implicated in the pathogenesis of various acute and chronic inflammatory diseases. In 1993, D-dopachrome tautomerase (D-DT) was discovered during an investigation of melanogenesis. The tertiary structure of D-DT is remarkably similar to MIF, identifying D-DT as the only known eukaryotic MIF homologue discovered to date. Despite D-DT?s intriguing similarities to the very well studied MIF, there have been very few reports on the biological functions and mechanisms of action of D-DT. This dissertation aimed at the functional characterization of D-DT in biological and pathophysiologic conditions.
Medie | Bøger Paperback Bog (Bog med blødt omslag og limet ryg) |
Udgivet | 23. februar 2012 |
ISBN13 | 9783838131610 |
Forlag | Südwestdeutscher Verlag für Hochschulsch |
Antal sider | 100 |
Mål | 150 × 6 × 226 mm · 158 g |
Sprog | Engelsk |
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