The use of the available research evidence to crack the padlock of SARS-CoV-2

It was known earlier that although, SARS-CoV was controlled more than a decade ago, more SARS-like coronaviruses which have been isolated in bats can use the human angiotensin converting enzyme-2 (ACE2) receptor to replicate to high levels in primary human airway, and they had the potential to cause new epidemics. Now, we should remember that it was concluded from earlier experiences that the first and most effective line of defense against a new viral pandemic in the early phases, are antiviral drugs not vaccines developed after rather a lengthy time. The unexpected high mortality associated with the ongoing SARS-CoV-2 in countries like the United States and the United Kingdom confirmed the earlier scientific prediction of the inadequate preparedness of the world to victoriously combat a new virus pandemic. The rational scientific approach to face a potentially fatal viral pandemic with no known effective specific therapies dictate the early use of all the useful preliminary research evidence with prioritizing emphasis on safety to avoid making more harm than good in such situation. We have previously published an evidence-based keys to the therapeutic challenge associated with the emergence of SARS-CoV-2 pandemic. The aim of this paper is to provide and important updates to keys to the therapeutic challenge which are hoped to help in cracking the padlock of SARS-CoV-2.